Tumour-associated macrophages facilitate cancer progression, but whether they can be reprogrammed to elicit an anti-tumour response remains unclear. Deletion of the microRNA-processing enzyme Dicer is now shown to rewire macrophages to an anti-tumour mode, leading to an enhanced response to immunotherapy and inhibition of tumour progression.
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Lee, Y., Biswas, S. Rewiring macrophages for anti-tumour immunity. Nat Cell Biol 18, 718–720 (2016). https://doi.org/10.1038/ncb3384
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DOI: https://doi.org/10.1038/ncb3384
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