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A motor relay on ciliary tracks

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A powerful combination of two-colour imaging in vivo, Fourier-filtered kymography and simulations provides a high-resolution view of kinesin-2 transport dynamics in cilia. This study reveals heterotrimeric kinesin-II as an 'obstacle-course runner' and homodimeric OSM-3 (KIF17) as a 'long-distance runner', and elucidates the 'baton handoff' between these two kinesin-2 motors on the microtubule track.

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Figure 1: A simple model of complex cooperation between anterograde motors in C. elegans phasmid cilia.

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Acknowledgements

The authors are supported by NJCSCR grant CSCR15IRG014 (R.O.) and NIH grants DK059418 and DK074746 (M.B.).

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  1. Human Genetics Institute and Department of Genetics, Robert O'Hagan and Maureen M. Barr are at Rutgers University, 145 Bevier Road, Piscataway, New Jersey 08854, USA,

    Robert O'Hagan & Maureen M. Barr

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  1. Robert O'Hagan
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  2. Maureen M. Barr
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Correspondence to Maureen M. Barr.

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O'Hagan, R., Barr, M. A motor relay on ciliary tracks. Nat Cell Biol 17, 1517–1519 (2015). https://doi.org/10.1038/ncb3279

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