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RNF138 joins the HR team

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Two studies show that the E3 ubiquitin ligase RNF138 is recruited to DNA double-strand break sites, where it ubiquitylates key repair factors to promote DNA-end resection and homologous recombination. These findings add insights into the multilayered regulatory mechanisms underlying DNA double-strand break repair pathway choice in mammalian cells.

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Figure 1: Model of RNF138-mediated DSB end resection and HR.

References

  1. Chapman, J. R., Taylor, M. R. & Boulton, S. J. Mol. Cell 47, 497–510 (2012).

    Article  CAS  PubMed  Google Scholar 

  2. Bekker-Jensen, S. & Mailand, N. DNA Repair 9, 1219–1228 (2010).

    Article  CAS  PubMed  Google Scholar 

  3. Ismail, I. H. et al. Nat. Cell Biol. 17, 1446–1457 (2015).

    Article  CAS  PubMed  Google Scholar 

  4. Schmidt, C. K. et al. Nat. Cell Biol. 17, 1458–1470 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Lieber, M. R. Annu. Rev. Biochem. 79, 181–211 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Heyer, W. D., Ehmsen, K. T. & Liu, J. Annu. Rev. Genet. 44, 113–139 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Jackson, S. P. & Durocher, D. Mol. Cell 49, 795–807 (2013).

    Article  CAS  PubMed  Google Scholar 

  8. Murakawa, Y. et al. Cancer Res. 67, 8536–8543 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Feng, L. & Chen, J. Nat. Struct. Mol. Biol. 19, 201–206 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Postow, L. & Funabiki, H. Cell Cycle 12, 587–595 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Dantuma, N. P., Acs, K. & Luijsterburg, M. S. Exp. Cell Res. 329, 9–17 (2014).

    Article  CAS  PubMed  Google Scholar 

  12. Makharashvili, N. & Paull, T. T. DNA Repair 32, 75–81 (2015).

    Article  CAS  PubMed  Google Scholar 

  13. Povlsen, L. K. et al. Nat. Cell Biol. 14, 1089–1098 (2012).

    Article  CAS  PubMed  Google Scholar 

  14. Elia, A. E. et al. Mol. Cell 59, 867–881 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Nishi, R. et al. Nat. Cell Biol. 16, 1016–1026 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Simon Bekker-Jensen and Niels Mailand are in the Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark,

    Simon Bekker-Jensen & Niels Mailand

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  1. Simon Bekker-Jensen
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  2. Niels Mailand
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Correspondence to Niels Mailand.

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The authors declare no competing financial interests.

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Bekker-Jensen, S., Mailand, N. RNF138 joins the HR team. Nat Cell Biol 17, 1375–1377 (2015). https://doi.org/10.1038/ncb3262

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