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Rubicon swaps autophagy for LAP

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Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubicon in the immune response to Aspergillus fumigatus.

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Figure 1: Macroautophagy versus LC3-associated phagocytosis.
Figure 2: Rubicon orchestrates the LAP response.

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Authors and Affiliations

  1. Division of Protein and Nucleic Acid Chemistry, Keith B. Boyle and Felix Randow are at MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK,

    Keith B. Boyle & Felix Randow

  2. Felix Randow is also in the Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK,

    Felix Randow

Authors
  1. Keith B. Boyle
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  2. Felix Randow
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Correspondence to Keith B. Boyle or Felix Randow.

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The authors declare no competing financial interests.

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Boyle, K., Randow, F. Rubicon swaps autophagy for LAP. Nat Cell Biol 17, 843–845 (2015). https://doi.org/10.1038/ncb3197

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