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A niche role for cancer exosomes in metastasis

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Cancer cells are known to secrete exosomes with pro-metastatic effects. Pancreatic-cancer-derived exosomes are now shown to promote liver metastasis by eliciting pre-metastatic niche formation through a multi-step process. This involves uptake of exosome-derived factors by liver Kupffer cells and hepatic stellate cell activation to generate a fibrotic microenvironment with immune cell infiltrates that favours metastasis.

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Figure 1: The sequential steps in liver pre-metastatic niche formation induced by PDAC-derived exosomes.

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Authors and Affiliations

  1. Yun Zhang is at the Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA,

    Yun Zhang

  2. Xiao-Fan Wang is in the Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA,

    Xiao-Fan Wang

Authors
  1. Yun Zhang
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  2. Xiao-Fan Wang
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Correspondence to Xiao-Fan Wang.

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The authors declare no competing financial interests.

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Zhang, Y., Wang, XF. A niche role for cancer exosomes in metastasis. Nat Cell Biol 17, 709–711 (2015). https://doi.org/10.1038/ncb3181

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