Skip to main content
SpringerLink
Log in

Gut healing: haemocytes aid via Sax and Tkv jazzes it down

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Control of stem cell activity is essential for accurate regeneration. Pathogen- or chemical-induced intestinal damage is now shown to recruit haemocytes expressing bone morphogenetic protein signals that stimulate proliferation of intestinal stem cells and subsequently induce their quiescence, in conjunction with muscle-derived bone morphogenetic proteins. A temporal switch in expression of Type I receptors enables this two-phase response.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Temporal control of regeneration by differential Dpp signalling to intestinal stem cells.

References

  1. Buchon, N., Broderick, N. A., Kuraishi, T. & Lemaitre, B. BMC Biol. 8, 152 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Ayyaz, A., Li, H. & Jasper, H. Nat. Cell Biol. 17, 736–748 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Lucchetta, E. M. & Ohlstein, B. Wiley Interdiscip. Rev. Dev. Biol. 1, 781–788 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Guo, Z., Driver, I. & Ohlstein, B. J. Cell Biol. 201, 945–961 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Li, H., Qi, Y. & Jasper, H. Cell Rep. 4, 10–18 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Tian, A. & Jiang, J. eLife 3, e01857 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Zhou, J. et al. Dev. Biol. 399, 189–203 (2015).

    Article  CAS  PubMed  Google Scholar 

  8. Harris, R. E. & Ashe, H. L. EMBO Rep. 12, 519–526 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Moustakas, A. & Heldin, C. H. Development 136, 3699–3714 (2009).

    Article  CAS  PubMed  Google Scholar 

  10. Bangi, E. & Wharton, K. Development 133, 3295–3303 (2006).

    Article  CAS  PubMed  Google Scholar 

  11. Aurora, A. B. & Olson, E. N. Cell Stem Cell 15, 14–25 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ables, E. T., Laws, K. M. & Drummond-Barbosa, D. Wiley Interdiscip. Rev. Dev. Biol. 1, 657–674 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Biteau, B., Hochmuth, C. E. & Jasper, H. Cell Stem Cell 9, 402–411 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Villeda, S. A. et al. Nature 477, 90–94 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Gopinath, S. D. & Rando, T. A. Aging Cell 7, 590–598 (2008).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lesley N. Weaver and Daniela Drummond-Barbosa are in the Department of Biochemistry and Molecular Biology and the Division of Reproductive Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 21205, USA,

    Lesley N. Weaver & Daniela Drummond-Barbosa

  2. Daniela Drummond-Barbosa is also in the Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland, 21205, USA,

    Daniela Drummond-Barbosa

Authors
  1. Lesley N. Weaver
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Daniela Drummond-Barbosa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniela Drummond-Barbosa.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Weaver, L., Drummond-Barbosa, D. Gut healing: haemocytes aid via Sax and Tkv jazzes it down. Nat Cell Biol 17, 707–709 (2015). https://doi.org/10.1038/ncb3178

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3178

  • Springer Nature Limited

Search

Navigation