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Control of ciliation in embryogenesis

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The protrusion of cilia into extracellular space provides cells with sensors of localized environmental cues that include fluid flow, mechanical force and important growth factors such as Hedgehog. Live imaging has now captured the initial appearance of cilia during embryogenesis, and defined lineage-specific determinants that restrict extra-embryonal ciliogenesis.

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Figure 1: Primary cilia expression depends on embryonic stage and cell lineage.
Figure 2: NEDD9 and AURKA activation of HDAC6 inhibits the primary cilium on XEN cells.

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Authors and Affiliations

  1. Anna S. Nikonova and Erica A. Golemis are in the Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA,

    Anna S. Nikonova & Erica A. Golemis

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  1. Anna S. Nikonova
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  2. Erica A. Golemis
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Correspondence to Erica A. Golemis.

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The authors declare no competing financial interests.

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Nikonova, A., Golemis, E. Control of ciliation in embryogenesis. Nat Cell Biol 17, 109–111 (2015). https://doi.org/10.1038/ncb3103

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