The endoderm layer destined to be primitive gut is a mosaic of earlier visceral endoderm and definitive endoderm that arises later, during gastrulation. Live imaging now reveals that in mouse embryos, definitive endoderm cells egress from underlying mesoderm and intercalate into the overlying cell layer. This process requires SOX17-mediated control of basement membrane organization.
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McDonald, A., Rossant, J. Gut endoderm takes flight from the wings of mesoderm. Nat Cell Biol 16, 1128–1129 (2014). https://doi.org/10.1038/ncb3077
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DOI: https://doi.org/10.1038/ncb3077
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