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Anti-tubulins DEPendably induce apoptosis

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Anti-tubulin drugs are life-saving chemotherapeutics that kill cancer cells by stabilizing or disrupting microtubules. Despite their clinical utility, the molecular mechanisms by which anti-tubulins cause apoptotic cell death remain poorly understood. It is now shown that microtubule disruption can inhibit anti-apoptotic Bcl-2 family proteins through an evolutionarily conserved signalling axis involving DEPDC1 (LET-99 in Caenorhabditis elegans) and JNK.

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Figure 1: Mechanisms of anti-tubulin-induced cell death.

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Authors and Affiliations

  1. Department of Biology, Daniel P. Denning and Takashi Hirose are at the Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA,

    Daniel P. Denning & Takashi Hirose

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  1. Daniel P. Denning
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  2. Takashi Hirose
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Correspondence to Daniel P. Denning or Takashi Hirose.

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The authors declare no competing financial interests.

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Denning, D., Hirose, T. Anti-tubulins DEPendably induce apoptosis. Nat Cell Biol 16, 741–743 (2014). https://doi.org/10.1038/ncb3012

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