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Neural stem cell quiescence comes to an un-sticky end

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Cell–cell interactions, a key feature of the stem cell niche, regulate many aspects of stem cell behaviour. N-cadherin-mediated anchorage of neural stem cells within the adult neural niche maintains stem cell quiescence, and its release by the metalloproteinase MT5-MMP promotes neural stem cell activation.

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Figure 1: Perturbations of cell–cell adhesion alter neural stem cell behaviour in the adult subventricular zone (SVZ) niche.

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Authors and Affiliations

  1. Katherine R. Long and Charles ffrench-Constant are at the MRC Centre for Regenerative Medicine, SCRM Building, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK,

    Katherine R. Long & Charles ffrench-Constant

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  1. Katherine R. Long
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  2. Charles ffrench-Constant
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Correspondence to Katherine R. Long or Charles ffrench-Constant.

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The authors declare no competing financial interests.

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Long, K., ffrench-Constant, C. Neural stem cell quiescence comes to an un-sticky end. Nat Cell Biol 16, 625–627 (2014). https://doi.org/10.1038/ncb3003

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