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Selective autophagy goes exclusive

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Using in vitro reconstitution systems, three studies shed light on the interactions of Atg8 family proteins with cargo receptors and components of the basal autophagy machinery. The results have important mechanistic implications for selective macroautophagy, scaffold formation and spatio-temporal organization of the lipidation process during autophagosome formation.

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Figure 1: Roles of Atg8 family proteins in exclusive selective autophagy, phagophore expansion and stabilization of membrane curvature.

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Authors and Affiliations

  1. Terje Johansen and Trond Lamark are in the Department of Medical Biology, Faculty of Health Sciences, University of Tromsø — The Arctic University of Norway, NO-9037, Tromsø, Norway,

    Terje Johansen & Trond Lamark

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  1. Terje Johansen
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  2. Trond Lamark
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Correspondence to Terje Johansen.

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Johansen, T., Lamark, T. Selective autophagy goes exclusive. Nat Cell Biol 16, 395–397 (2014). https://doi.org/10.1038/ncb2961

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