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p73 keeps metabolic control in the family

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The transcription factor p73, a close relative of p53, has complex yet poorly understood roles in tumorigenesis. TAp73, a p73 variant, has now been shown to promote cancer cell proliferation by regulating glucose metabolism to control cellular biosynthetic pathways and antioxidant capacity.

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Figure 1: In addition to glycolysis, glucose can be metabolized through the pentose phosphate pathway (PPP) to generate ribose-5-phosphate, a precursor of nucleotides.

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Authors and Affiliations

  1. Louise Fets and Dimitrios Anastasiou are in the Division of Physiology and Metabolism, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK,

    Louise Fets & Dimitrios Anastasiou

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  1. Louise Fets
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  2. Dimitrios Anastasiou
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Correspondence to Dimitrios Anastasiou.

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The authors declare no competing financial interests.

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Fets, L., Anastasiou, D. p73 keeps metabolic control in the family. Nat Cell Biol 15, 891–893 (2013). https://doi.org/10.1038/ncb2810

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