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Preventing lysosomal fat indigestion

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Autophagy contributes to lipid catabolism through direct mobilization and breakdown of cellular lipid stores. Two recent studies reveal the regulatory mechanisms activated by cells during starvation to ensure that the cellular compartments involved in autophagic lipid catabolism are ready to receive, process and use these lipids. The regulators represent attractive therapeutic targets to help fight lipid-excess-associated diseases.

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Figure 1: Coordinated transcriptional regulation of lipid metabolism by autophagy.
Figure 2: Therapeutic potential of the regulation of the TFEB transcriptional program.

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Authors and Affiliations

  1. Ana Maria Cuervo is in the Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York 10461, USA,

    Ana Maria Cuervo

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  1. Ana Maria Cuervo
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Correspondence to Ana Maria Cuervo.

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The author declares no competing financial interests.

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Cuervo, A. Preventing lysosomal fat indigestion. Nat Cell Biol 15, 565–567 (2013). https://doi.org/10.1038/ncb2778

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