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Cullin' PLK1 from kinetochores

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To ensure proper attachment of all chromosomes to the spindle, PLK1 has to associate with kinetochores during prometaphase and must be released from these sites before sister chromatid separation can begin. The monoubiquitylation of PLK1 by the ubiquitin ligase CUL3–KLHL22 is now identified as a critical step in promoting the release of PLK1 from kinetochores, pushing non-proteolytic ubiquitylation into the limelight of cell division research.

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Figure 1: Monoubiquitylation triggers PLK1 dissociation from kinetochores.

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Authors and Affiliations

  1. Colleen A. McGourty and Michael Rape are in the Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA,

    Colleen A. McGourty & Michael Rape

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  1. Colleen A. McGourty
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  2. Michael Rape
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Correspondence to Michael Rape.

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The authors declare no competing financial interests.

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McGourty, C., Rape, M. Cullin' PLK1 from kinetochores. Nat Cell Biol 15, 347–348 (2013). https://doi.org/10.1038/ncb2722

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