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Formin' cables under stress

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How application of force affects actin remodelling during mechanotransduction has remained unclear. Mechanical manipulation of the cell cortex is now shown to trigger actin monomer release from filaments, which in turn activates formin-dependent actin filament elongation. This force-sensitive actin polymerization does not require GTPases or membrane receptors, but it involves actin itself.

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Figure 1: Proposed model of mechanosensitive, formin-mediated actin filament elongation.

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  1. Deborah Leckband is in the Department of Chemical and Biomolecular Engineering, Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA,

    Deborah Leckband

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  1. Deborah Leckband
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Correspondence to Deborah Leckband.

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Leckband, D. Formin' cables under stress. Nat Cell Biol 15, 345–346 (2013). https://doi.org/10.1038/ncb2715

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