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Connecting membrane traffic to ESCRT and the final cut

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The ESCRT (endosomal sorting complex required for transport) machinery is responsible for scission of the cytokinetic bridge that connects daughter cells at the end of mitosis. Specific endosomes are now found to mediate local bridge constriction and actin clearance in human cells, which contribute to the recruitment of ESCRT components at the abscission site.

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Figure 1: A model of cytokinesis abscission integrating membrane traffic and cytoskeleton dynamics.

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Authors and Affiliations

  1. Membrane Traffic and Cell Division Laboratory, Arnaud Echard is in the Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France, and in the CNRS URA2582, France,

    Arnaud Echard

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  1. Arnaud Echard
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Correspondence to Arnaud Echard.

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Echard, A. Connecting membrane traffic to ESCRT and the final cut. Nat Cell Biol 14, 983–985 (2012). https://doi.org/10.1038/ncb2598

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