In a large-scale analysis, the effects of DNA damage on the levels and localization of almost every protein in an organism have now been tracked in living cells. It is shown that that although many proteins change their position or concentration, they rarely do both.
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References
Jackson, S. P. & Bartek, J. Nature 461, 1071–1078 (2009).
Huh, W.-K. et al. Nature 425, 686–691 (2003).
Ghaemmaghami, S. et al. Nature 425, 737–741 (2003).
Tkach, J. M. et al. Nat. Cell Biol. 14, 966–976 (2012).
Alvaro, D., Lisby, M. & Rothstein, R. PLoS Genet. 3, e228 (2007).
Neumann, B. et al. Nature 464, 721–727 (2010).
Vizeacoumar, F. J. et al. J. Cell Biol. 188, 69–81 (2010).
Kamentsky, L. et al. Bioinformatics 27, 1179–1180 (2011).
Addinall, S. G. et al. Genetics 180, 2251–2266 (2008).
Gatbonton, T. et al. PLoS Genet. 2, e35 (2006).
Collins, S. R. et al. Nature 446, 806–810 (2007).
Chang, M. et al. Genetics 183, 779–791 (2009).
Hillenmeyer, M. E. et al. Science 320, 362–365 (2008).
Parsons, A. B. et al. Nat. Biotech. 22, 62–69 (2004).
Serero, A., Lopes, J., Nicolas, A. & Boiteux, S. DNA Repair 7, 1262–1275 (2008).
Makhnevych, T. et al. Mol. Cell 33, 124–135 (2009).
Herrero, A. B. & Moreno, S. EMBO J. 30, 2008–2018 (2011).
Swedlow, J. R. Nat. Cell Biol. 13, 183 (2011).
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Thorpe, P., Rothstein, R. Visualizing global effects of the DNA damage response. Nat Cell Biol 14, 900–901 (2012). https://doi.org/10.1038/ncb2571
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DOI: https://doi.org/10.1038/ncb2571
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