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Get on the exosome bus with ALIX

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Exosomes have a growing inventory of functions, but the mechanism of protein sorting into exosomes has been unclear. Now, a signal sequence first described in viral budding provides just such a cargo sorting mechanism, revealing closer-than-expected parallelism between exosome biogenesis and the ESCRT-dependent endolysosomal pathway.

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Figure 1: Roles of multivesicular bodies in exosome biogenesis and lysosomal protein sorting.

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Authors and Affiliations

  1. James H. Hurley is at the Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA,

    James H. Hurley

  2. Greg Odorizzi is at the Department of Molecular, Cell and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA,

    Greg Odorizzi

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  1. James H. Hurley
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  2. Greg Odorizzi
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Correspondence to James H. Hurley or Greg Odorizzi.

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The authors declare no competing financial interests.

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Hurley, J., Odorizzi, G. Get on the exosome bus with ALIX. Nat Cell Biol 14, 654–655 (2012). https://doi.org/10.1038/ncb2530

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