Skip to main content
SpringerLink
Log in

Cdc25A and Dub3 in a high-stakes balancing act

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

The deubiquitylating enzyme Dub3 is found to have oncogenic potential by stabilizing the Cdc25A protein phosphatase, a crucial regulator of cell-cycle progression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Multiple E3 ubiquitin ligases, checkpoint kinases, and the deubiquitylating enzyme Dub3 control Cdc25A stability and activity during the cell cycle.

References

  1. Loffler, H. et al. Oncogene 22, 8063–8071 (2003).

    Article  Google Scholar 

  2. Boutros, R., Lobjois, V. & Ducommun, B. Nature Rev. Cancer 7, 495–507 (2007).

    Article  CAS  Google Scholar 

  3. Pereg, Y. et al. Nature Cell Biol. 12, 400–406 (2010).

    Article  CAS  Google Scholar 

  4. Malumbres, M. & Barbacid, M. Trends Biochem. Sci. 30, 630–641 (2005).

    Article  CAS  Google Scholar 

  5. Lee, G., White, L. S., Hurov, K. E., Stappenbeck, T. S. & Piwnica-Worms, H. Proc. Natl Acad. Sci. USA 106, 4701–4706 (2009).

    Article  CAS  Google Scholar 

  6. Busino, L., Chiesa, M., Draetta, G. F. & Donzelli, M. Oncogene 2 3, 2050–2056 (2004).

    Article  Google Scholar 

  7. Melixetian, M., Klein, D. K., Sorensen, C. S. & Helin, K. Nature Cell Biol. 11, 1247–1253 (2009).

    Article  CAS  Google Scholar 

  8. Welcker, M. & Clurman, B. E. Nature Rev. Cancer 8, 83–93 (2008).

    Article  CAS  Google Scholar 

  9. Komander, D., Clague, M. J. & Urbe, S. Nature Rev. Mol. Cell Biol. 10, 550–563 (2009).

    Article  CAS  Google Scholar 

  10. Shan, J., Zhao, W. & Gu, W. Mol. Cell 36, 469–476 (2009).

    Article  CAS  Google Scholar 

  11. Stevenson, L. F. et al. EMBO J. 26, 976–986 (2007).

    Article  CAS  Google Scholar 

  12. Luo, J., Solimini, N. L. & Elledge, S. J. Cell 136, 823–837 (2009).

    Article  CAS  Google Scholar 

  13. Sowa, M. E., Bennett, E. J., Gygi, S. P. & Harper, J. W. Cell 138, 389–403 (2009).

    Article  CAS  Google Scholar 

  14. Burrows, J. F., McGrattan, M. J. & Johnston, J. A. Genomics 85, 524–529 (2005).

    Article  CAS  Google Scholar 

  15. Nicolini, A., Carpi, A. & Rossi, G. Cytokine Growth Factor Rev. 17, 325–337 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sebastian D. Hayes and J. Wade Harper are in the Department of Pathology, Harvard Medical School, Boston MA 02115, USA. wade_harper@hms.harvard.edu,

    Sebastian D. Hayes & J. Wade Harper

Authors
  1. Sebastian D. Hayes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Wade Harper
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hayes, S., Harper, J. Cdc25A and Dub3 in a high-stakes balancing act. Nat Cell Biol 12, 311–313 (2010). https://doi.org/10.1038/ncb2043

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb2043

  • Springer Nature Limited

This article is cited by

Search

Navigation