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Checkpoint signalling: focusing on 53BP1

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The p53-binding protein 53BP1 has been implicated in DNA damage responses. Three new reports indicate that 53BP1 is central to both the S and G2 checkpoints after exposure to ionizing radiation (IR). 53BP1 participates in the organization of nuclear foci and facilitates the phosphorylation of specific substrates by the checkpoint kinase, ataxia-telangiectasia mutated (ATM).

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Figure 1: Schematic representation of the 53BP1-dependent checkpoint pathway.

References

  1. Iwabuchi, K., Bartel, P. L., Li, B., Marraccino, R. & Fields, S. Proc. Natl Acad. Sci. USA 91, 6098–6102 (1994).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Iwabuchi, K. et al. J. Biol. Chem. 273, 26061–26068 (1998).

    Article  CAS  PubMed  Google Scholar 

  3. Chai, Y. L. et al. Oncogene 18, 263–268 (1999).

    Article  CAS  PubMed  Google Scholar 

  4. Bork, P. et al. FASEB J. 11, 68–76 (1997).

    Article  CAS  PubMed  Google Scholar 

  5. Derbyshire, D. J. et al. EMBO J. 21, 3863–3872 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Joo, W. S. et al. Genes Dev. 16, 583–593 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Anderson, L., Henderson, C. & Adachi, Y. Mol. Cell Biol. 21, 1719–1729 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Rappold, I., Iwabuchi, K., Date, T. & Chen, J. J. Cell Biol. 153, 613–620 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Schultz, L. B., Chehab, N. H., Malikzay, A. & Halazonetis, T. D. J. Cell Biol. 151, 1381–1390 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Wang, B., Matsuoka, S., Carpenter, P. B. & Elledge, S. J. Science 298, 1435–1438 (2002).

    Article  CAS  PubMed  Google Scholar 

  11. Fernandez-Capetillo, O. et al. Nature Cell Biol. 4, 993–997 (2002).

    Article  CAS  PubMed  Google Scholar 

  12. DiTullio, J. R., et al. Nature Cell Biol. 4, 998–1002 (2002).

    Article  CAS  PubMed  Google Scholar 

  13. Zhou, B. B. S. & Elledge, S. J. Nature 408, 433–439 (2000).

    Article  CAS  PubMed  Google Scholar 

  14. Xu, B., Kim, S. T., Lim, D. S. & Kastan, M. B. Mol. Cell Biol. 22, 1049–1059 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. McGowan, C. H. Bioessays 24, 502–511 (2002).

    Article  CAS  PubMed  Google Scholar 

  16. Ward, I. M., Wu, X. & Chen, J. J. Biol. Chem. 276, 47755–47758 (2001).

    Article  CAS  PubMed  Google Scholar 

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  1. The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, 92037, CA, USA

    Robert T. Abraham

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Abraham, R. Checkpoint signalling: focusing on 53BP1. Nat Cell Biol 4, E277–E279 (2002). https://doi.org/10.1038/ncb1202-e277

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