The tumour suppressor Tip60 is a histone acetyltransferase implicated in transcriptional control and DNA double-strand break repair. Tip60 binds to the heterochromatic histone mark H3K9me3, triggering acetylation and activation of DNA double-strand break repair factors.
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Fischle, W. Tip60-ing the balance in DSB repair. Nat Cell Biol 11, 1279–1281 (2009). https://doi.org/10.1038/ncb1109-1279
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DOI: https://doi.org/10.1038/ncb1109-1279
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