The balance between proliferation and differentiation is essential not only for the generation and maintenance of tissues, but also to prevent uncontrolled cell division and tumorigenesis. The mitotic kinase Aurora A coordinates cell-cycle events and asymmetric division by regulating localization of the cell fate determinant Numb through remodelling of the conserved PAR polarity complex.
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Brand, A. A new dawn for Aurora?. Nat Cell Biol 10, 1253–1254 (2008). https://doi.org/10.1038/ncb1108-1253
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DOI: https://doi.org/10.1038/ncb1108-1253
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