Trans-tail regulation is the linked post-translational modification of tails on different histones. Two important studies implicate Swd2 as the link between H2B ubiquitylation and H3 methylation. Swd2 is a component of both the SET1 methyltransferase complex and the cleavage and polyadenylation factor CPF, implicating trans-tail regulation in differentiating events at the beginning and end of genes.
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Mellor, J. On your MARKS, get SET, METHYLATE!. Nat Cell Biol 10, 1249–1250 (2008). https://doi.org/10.1038/ncb1108-1249
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DOI: https://doi.org/10.1038/ncb1108-1249
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