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A motor driving PTEN

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To fulfil its lipid phosphatase function, PTEN must be in close proximity to the plasma membrane where its substrates reside. PTEN translocation to the plasma membrane is an active process that is mediated by the myosin-based transport machinery. MyosinV controls PTEN membrane association and thus, PTEN-mediated cell growth in neurons.

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Figure 1: MyosinV controls PTEN transport to the plasma membrane and PTEN lipid phosphatase activity.

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Authors and Affiliations

  1. Jing Zhou and Luis F. Parada are in the Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. jing.zhou@utsouthwestern.edu; luis.parada@utsouthwestern.edu,

    Jing Zhou & Luis F. Parada

  2. luis.parada@utsouthwestern.edu,

    Jing Zhou & Luis F. Parada

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  1. Jing Zhou
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  2. Luis F. Parada
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Zhou, J., Parada, L. A motor driving PTEN. Nat Cell Biol 11, 1177–1179 (2009). https://doi.org/10.1038/ncb1009-1177

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