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Atg5: more than an autophagy factor

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Atg5 has been previously characterized as a protein specifically required for autophagy, a lysosomal catabolic pathway for proteins and organelles. However, it has now been shown that, in addition to its role in the formation of autophagosomes, an Atg5 fragment produced by calpain cleavage has pro-apoptotic properties.

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Figure 1: Partners of Atg5 and their role in autophagy and apoptosis.

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Authors and Affiliations

  1. the INSERM U756, University of Paris-Sud 11, 5, rue Jean-Baptiste Cleément, Châtenay-Malabry, 92296, France

    Patrice Codogno

  2. Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 15, AZ Amsterdam, 1105, The Netherlands

    Alfred J. Meijer

Authors
  1. Patrice Codogno
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  2. Alfred J. Meijer
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Codogno, P., Meijer, A. Atg5: more than an autophagy factor. Nat Cell Biol 8, 1045–1047 (2006). https://doi.org/10.1038/ncb1006-1045

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