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How attraction turns to repulsion

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During cell-contact-mediated repulsion, an initially adhesive interaction between a receptor and its ligand ultimately results in a repulsive response that causes the cells to separate. Two studies looking at the case of Eph receptors and ephrins now identify a crucial role for endocytosis in this enigmatic process.

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Figure 1: Conversion of adhesive interactions to repulsion.

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  1. Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    David G. Wilkinson

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  1. David G. Wilkinson
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Wilkinson, D. How attraction turns to repulsion. Nat Cell Biol 5, 851–853 (2003). https://doi.org/10.1038/ncb1003-851

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