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Ubiquitination, proteasomes and GABAA receptors

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Inhibitory neurotransmission by γ-aminobutyric acid (GABA) is regulated by the number and subcellular localization of GABAA receptors in the membrane of the target neuron. A new study suggests that the ubiquitin-like protein Plic-1 stabilizes intracellular GABAA receptors and promotes their accumulation in the plasma membrane.

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Figure 1: Trafficking and membrane targeting of GABAA receptors.

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Authors and Affiliations

  1. Department of Biology and the Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, 16802, USA

    Bernhard Lüscher & Cheryl A. Keller

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  1. Bernhard Lüscher
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  2. Cheryl A. Keller
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Lüscher, B., Keller, C. Ubiquitination, proteasomes and GABAA receptors. Nat Cell Biol 3, E232–E233 (2001). https://doi.org/10.1038/ncb1001-e232

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