Skip to main content
SpringerLink
Log in

Sugar-coated pathways for developmental patterning

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Signalling pathways controlling developmental cell fate rely on a variety of carbohydrate-based protein modifications, including glycosylation of cell-surface and extracellular-matrix proteins. Receptors themselves might be glycosylated during synthesis and secretory trafficking, regulating their subsequent signalling activities. Two recent reports have uncovered a shared requirement for nucleotide–sugar transport in these processes, underscoring the importance of carbohydrates in developmental patterning.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Glycosylation of proteins during their synthesis and secretory trafficking has multiple effects on developmental signalling at the cell surface.

References

  1. Selleck, S. B. Trends Genet. 16, 206–212 (2000).

    Article  CAS  Google Scholar 

  2. Moloney, D. J. et al. Nature 406, 369–375 (2000).

    Article  CAS  Google Scholar 

  3. Brückner, K., Perez, L., Clausen, H. & Cohen, S. Nature 406, 411–415 (2000).

    Article  Google Scholar 

  4. Hicks, C. et al. Nature Cell Biol. 2, 515–520 (2000).

    Article  CAS  Google Scholar 

  5. Munro, S. & Freeman, M. Curr. Biol. 10, 813–820 (2000).

    Article  CAS  Google Scholar 

  6. Selva, E. M. et al. Nature Cell Biol. 3, 809–815 (2001).

    Article  CAS  Google Scholar 

  7. Goto, S. et al. Nature Cell Biol. 3, 816–822 (2001).

    Article  CAS  Google Scholar 

  8. Perrimon, N., Lanjuin, A., Arnold, C. & Noll, E. Genetics 144, 1681–1692 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Lin, X. & Perrimon, N. Nature 400, 281–284 (1999).

    Article  CAS  Google Scholar 

  10. Tsuda, M. et al. Nature 400, 276–280 (1999).

    Article  CAS  Google Scholar 

  11. Häcker, U., Lin, X. & Perrimon, N. Development 124, 3565–3573 (1997).

    PubMed  Google Scholar 

  12. Binari, R. C. et al. Development 124, 2623–2632 (1997).

    CAS  PubMed  Google Scholar 

  13. Lin, X., Buff, E. M., Perrimon, N. & Michelson, A. M. Development 126, 3715–3723 (1999).

    CAS  PubMed  Google Scholar 

  14. Johansen, K. M., Fehon, R. G. & Artavanis-Tsakonas, S. J. Cell Biol. 109, 2427–2440 (1989).

    Article  CAS  Google Scholar 

  15. Kidd, S., Baylies, M. K., Gasic, G. P. & Young, M. W. Genes Dev 3, 1113–1129 (1989).

    Article  CAS  Google Scholar 

  16. Panin, V. M., Papayannopoulos, V., Wilson, R. & Irvine, K. D. Nature 387, 908–912 (1997).

    Article  CAS  Google Scholar 

  17. Weinmaster, G. Curr. Opin. Genet. Dev. 10, 363–369 (2000).

    Article  CAS  Google Scholar 

  18. Bellaiche, Y., The, I. & Perrimon, N. Nature 394, 85–88 (1998).

    Article  CAS  Google Scholar 

  19. Pilia, G. et al. Nature Genet. 12, 241–247 (1996).

    Article  CAS  Google Scholar 

  20. McCormick, C. et al. Nature Genet. 19, 158–161 (1998).

    Article  CAS  Google Scholar 

  21. Karsan, A. et al. J. Clin. Invest. 101, 2438–2445 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genetics, University of Pennsylvania School of Medicine, Stellar-Chance Laboratories 709C, 422 Curie Boulevard, Philadelphia, 19104, Pennsylvania, USA

    Mark E. Fortini

Authors
  1. Mark E. Fortini
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fortini, M. Sugar-coated pathways for developmental patterning. Nat Cell Biol 3, E229–E231 (2001). https://doi.org/10.1038/ncb1001-e229

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb1001-e229

  • Springer Nature Limited

This article is cited by

Search

Navigation