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Twisted epithelial–mesenchymal transition blocks senescence

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The epithelial–mesenchymal transition (EMT) is a cellular transdifferentiation program that enables epithelial cancer cells to acquire traits of high-grade malignancy, notably invasive and metastatic powers. A new study indicates that it may also function early in tumour progression by preventing oncogene-induced senescence.

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Figure 1: Epithelial–mesenchymal transition (EMT) enables cancer cells to acquire malignant features such as invasiveness and resistance to chemotherapy.

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Authors and Affiliations

  1. MIT Department of Biology, Robert A. Weinberg is at the Whitehead Institute for Biomedical Research, Ludwig Center for Molecular Oncology, Cambridge MA 02142, USA. weinberg@wi.mit.edu,

    Robert A. Weinberg

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  1. Robert A. Weinberg
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Weinberg, R. Twisted epithelial–mesenchymal transition blocks senescence. Nat Cell Biol 10, 1021–1023 (2008). https://doi.org/10.1038/ncb0908-1021

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