Cool-1 was previously identified as an effector of activated Cdc42 and as a regulator of epidermal growth factor receptor (EGFR) trafficking. Cool-1 has now been shown to be a phosphorylation-dependent activator of Cdc42 that contributes to transformation by Src, thus proving to be an unusually versatile signalling protein.
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References
Timpson, P., Jones, G. E., Frame, M. C. & Brunton, V. G. Curr. Biol. 11, 1836–1846 (2001).
Tu, S., Wu, W. J., Wang, J. & Cerione, R. A. J. Biol. Chem. 278, 49293–49300 (2003).
Feng, Q. et al. Nature Cell Biol. 8, 945–956 (2006).
Bagrodia, S., Taylor, S. J., Jordon, K. A., Van Aelst, L. & Cerione, R. A. J. Biol. Chem. 273, 23633–23636 (1998).
Manser, E. et al. Mol. Cell 1, 183–192 (1998).
Feng, Q., Albeck, J. G., Cerione, R. A. & Yang, W. J. Biol. Chem. 277, 5644–5650 (2002).
Wu, W. J., Tu, S. & Cerione, R. A. Cell 114, 715–725 (2003).
Lambert, J. M. et al. Nature Cell Biol. 4, 621–625 (2002).
Margarit, S. M. et al. Cell 112, 685–695 (2003).
Baird, D., Feng, Q. & Cerione, R. A. Curr. Biol. 15, 1–10 (2005).
Flanders J. A. et al. FEBS Lett. 550, 119–123 (2003).
Swaminathan, G. & Tsygankov, A. Y. J. Cell Physiol. 209, 21–43 (2006).
Schmidt, M. H., Husnjak, K., Szymkiewicz, I., Haglund, K. & Dikic, I. Oncogene 25, 3071–3078 (2006).
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Peterson, J., Chernoff, J. Src transforms in a Cool way. Nat Cell Biol 8, 905–907 (2006). https://doi.org/10.1038/ncb0906-905
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DOI: https://doi.org/10.1038/ncb0906-905
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