Cell division in eukaryotes involves a complex self-organization process that drives the transient assembly of dynamic microtubules into a bipolar spindle around the chromosomes to segregate them to the two daughter cells. Spindle shape and size do not depend on the initial spatial organization of the chromatin, but are determined by microtubule motor activities.
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References
Kirschner, M. & Mitchison, T. Cell 45, 329–342 (1986).
Karsenti, E. & Vernos, I. Science 294, 543–547 (2001).
Wittmann, T., Hyman, A. & Desai, A. Nature Cell Biol. 3, E28–E34 (2001).
Sampath, S. C. et al. Cell 118, 187–202 (2004).
Niethammer, P., Bastiaens, P. & Karsenti, E. Science 303, 1862–1866 (2004).
Gruss, O. J. & Vernos, I. J. Cell Biol. 166, 949–955 (2004).
Kalab, P., Weis, K. & Heald, R. Science 295, 2452–2456 (2002).
Kalab, P., Pralle, A., Isacoff, E. Y., Heald, R. & Weis, K. Nature 440, 697–701 (2006).
Caudron, M., Bunt, G., Bastiaens, P. & Karsenti, E. Science 309, 1373–1376 (2005).
Bastiaens, P., Caudron, M., Niethammer, P. & Karsenti, E. Trends Cell Biol. 16, 125–134 (2006).
Gaetz, J., Gueroui, Z., Libchaber, A. & Kapoor, T. Nature Cell Biol. 8, 924–932 (2006).
Heald, R. et al. Nature 382, 420–425 (1996).
Walczak, C. E., Vernos, I., Mitchison, T. J., Karsenti, E. & Heald, R. Curr. Biol. 8, 903–913 (1998).
Goshima, G. & Vale, R. D. J. Cell Biol. 162, 1003–1016 (2003).
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Vernos, I. Only one spindle, if you please .... Nat Cell Biol 8, 901–902 (2006). https://doi.org/10.1038/ncb0906-901
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DOI: https://doi.org/10.1038/ncb0906-901
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