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Small-interfering RNAs in the radar of the interferon system

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The expanding use of small RNA technology to silence specific genes shows no signs of slowing down. However, the discovery that it can induce components of the interferon system in animal cells should make us pause to consider potential non-specific effects of this technique.

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Figure 1: Specific and potential non-specific effects of small RNA technology.

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Authors and Affiliations

  1. Department of Molecular Biology, UMDNJ, Stratford, 08084, NJ, USA

    Eric G. Moss

  2. Fox Chase Cancer Center, Philadelphia, 19111, PA, USA

    John M. Taylor

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  1. Eric G. Moss
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  2. John M. Taylor
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Moss, E., Taylor, J. Small-interfering RNAs in the radar of the interferon system. Nat Cell Biol 5, 771–772 (2003). https://doi.org/10.1038/ncb0903-771

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