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SASPense and DDRama in cancer and ageing

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Senescent cells alter their microenvironment by secreting a growing collection of factors, a phenomenon termed the senescence-associated secretory phenotype (SASP). Cellular senescence is often the result of nuclear DNA damage fuelling a chronic DNA damage response (DDR). Upstream elements of the DDR cascade are necessary for full blown SASP, and additional crosstalk occurs between the DDR and cytokine secretion.

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Figure 1: Induction, pro- and anti-tumour effects of the senescence-associated secretory phenotype.

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Authors and Affiliations

  1. Marzia Fumagalli and Fabrizio d'Adda di Fagagna are at the IFOM Foundation - FIRC Institute of Molecular Oncology Foundation, via Adamello 16, 20139 Milan, Italy. fabrizio.dadda@ifom-ieo-campus.it,

    Marzia Fumagalli & Fabrizio d'Adda di Fagagna

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  1. Marzia Fumagalli
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  2. Fabrizio d'Adda di Fagagna
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Fumagalli, M., d'Adda di Fagagna, F. SASPense and DDRama in cancer and ageing. Nat Cell Biol 11, 921–923 (2009). https://doi.org/10.1038/ncb0809-921

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