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Nutrient sensing: TOR's Ragtime

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The mammalian target of rapamycin (mTOR) controls cell growth and size. Amino acids are known to activate TOR, and Rag (Ras-related GTP-binding protein) GTPases have now been found to act as their effectors.

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Figure 1: Amino acids and mTOR signalling.

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Authors and Affiliations

  1. Alfred J. Meijer is in the Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands a.j.meijer@amc.uva.nl,

    Alfred J. Meijer

  2. Patrice Codogno is in the INSERM U756, University of Paris-Sud 11, 5, rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France.,

    Patrice Codogno

Authors
  1. Alfred J. Meijer
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  2. Patrice Codogno
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Meijer, A., Codogno, P. Nutrient sensing: TOR's Ragtime. Nat Cell Biol 10, 881–883 (2008). https://doi.org/10.1038/ncb0808-881

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