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Debugging cellular reprogramming

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Last year it was reported that a cocktail of four transcription factors — encoded by Oct4, Sox2, Myc and Klf4 — can partly reprogramme mouse somatic cells to an embryonic state, a process that reawakens silenced segments of the genome and restores pluripotency to the somatic cell nucleus. Three groups have now modified this method to generate fully reprogrammed cells that closely resemble embryonic stem cells.

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Figure 1: Past, present and future efforts at reprogramming with a cocktail of four transcription factors.

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Authors and Affiliations

  1. In-Hyun Park is in the Division of Pediatric Hematology/Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA.,

    In-Hyun Park

  2. George Q. Daley is in the Division of Pediatric Hematology/Oncology, Department of Biological Chemistry and Molecular Pharmacology, Division of Hematology, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA, Harvard Medical School, Boston, MA 02115, USA, Brigham and Women's Hospital, Boston, MA 02115, USA, and Harvard Stem Cell Institute, Boston, MA 02115, USA. George.Daley@childrens.harvard.edu,

    George Q. Daley

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  1. In-Hyun Park
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Park, IH., Daley, G. Debugging cellular reprogramming. Nat Cell Biol 9, 871–873 (2007). https://doi.org/10.1038/ncb0807-871

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