Ubiquitin, best known as a degradation signal, is also a protein-sorting tag on endocytic cargoes and a regulatory switch on endocytic adaptor proteins. Parkin, a ubiquitin ligase whose mutations are associated with Parkinson's disease, has now been shown to control EGF-receptor internalization and Akt signalling by ubiquitination of the endocytic scaffold protein Eps15.
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References
Di Fiore, P. P. & De Camilli, P. Cell 106, 1–4 (2001).
Haglund, K. & Dikic, I. EMBO J. 24, 3353–3359 (2005).
Hicke, L., Schubert, H.L. & Hill, C.P. Nature Rev. Mol. Cell Biol. 6, 610–621 (2005).
Polo, S. et al. Nature 416, 451–455 (2002).
Hoeller, D. et al. Nature Cell Biol. 8, 163–169 (2006).
van Delft, S., Govers, R., Strous, G. J., Verkleij, A.J. & van Bergen en Henegouwen, P. M. J. Biol. Chem. 272, 14013–14016 (1997).
Fallon, L. et al. Nature Cell Biol. 8, 834–842 (2006).
Chung, K. K. et al. Nature Med. 7, 1144–1150 (2001).
Huynh, D. P., Scoles, D. R., Nguyen, D. & Pulst, S. M. Hum. Mol. Genet. 12, 2587–2597 (2003).
Ren, Y., Zhao, J. & Feng, J. J. Neurosci. 23, 3316–3324 (2003).
Sigismund, S. et al. Proc. Natl Acad. Sci. USA 102, 2760–2765 (2005).
Iwakura, Y. et al. J. Neurochem. 93, 974–983 (2005).
Cookson, M. R. Annu. Rev. Biochem. 74, 29–52 (2005).
Sakata, E. et al. EMBO Rep. 3, 301–306 (2003).
Tsai, Y. C., Fishman, P. S., Thakor, N. V. & Oyler, G.A. J. Biol. Chem. 278, 22044–22055 (2003).
Dachsel, J. C. et al. FEBS Lett. 579, 3913–3919 (2005).
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Husnjak, K., Dikic, I. EGFR trafficking: parkin' in a jam. Nat Cell Biol 8, 787–788 (2006). https://doi.org/10.1038/ncb0806-787
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DOI: https://doi.org/10.1038/ncb0806-787
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