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Front and back by Rho and Rac

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The RhoGTPases Rac and Rho are important for orchestrating cytoskeletal dynamics during cell migration and crosstalk to antagonize each others' activities. The discovery of a Rac GTPase activating protein (GAP) that is regulated by Rho and Rho kinase (ROCK) provides a new basis for this crosstalk.

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Figure 1: FilGAP regulates Rac activity downstream from Rho and ROCK.

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Authors and Affiliations

  1. the Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599-7295, NC, USA

    Keith Burridge & Renee Doughman

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  1. Keith Burridge
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  2. Renee Doughman
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Burridge, K., Doughman, R. Front and back by Rho and Rac. Nat Cell Biol 8, 781–782 (2006). https://doi.org/10.1038/ncb0806-781

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