The RhoGTPases Rac and Rho are important for orchestrating cytoskeletal dynamics during cell migration and crosstalk to antagonize each others' activities. The discovery of a Rac GTPase activating protein (GAP) that is regulated by Rho and Rho kinase (ROCK) provides a new basis for this crosstalk.
References
Ohta, Y., Hartwig, J. H. & Stossel,T. P. Nature Cell Biol. 8, 803–814 (2006).
Stossel, T. P. et al. Nature Rev. Mol. Cell Biol. 2, 138–145 (2001).
Higashida, C. et al. Science 303, 2007–2010 (2004).
Kurokawa, K. & Matsuda, M. Mol. Biol. Cell 16, 4294–4303 (2005).
Tsuji, T. et al. J. Cell Biol. 157, 819–830 (2002).
Worthylake, R. A. & Burridge, K. J Biol. Chem. 278, 13578–13584 (2003).
Xu, J. et al. Cell 114, 201–214 (2003).
Pertz, O., Hodgson, L., Klemke, R. L. & Hahn, K. M. Nature 440, 1069–1072 (2006).
Nimnual, A. S., Yatsula, B. A. & Bar-Sagi, D. Nature Cell Biol. 5, 236–241 (2003).
Kraynov, V. S. et al. Science 290, 333–337 (2000).
Kurokawa, K., Itoh, R. E., Yoshizaki, H., Nakamura, Y. O. & Matsuda, M. Mol. Biol. Cell 15, 1003–1010 (2004).
Svitkina, T. M. & Borisy, G. G. J. Cell Biol. 145, 1009–1026 (1999).
Ghosh, M. et al. Science 304, 743–746 (2004).
Wong, K., Pertz, O., Hahn, K. & Bourne, H. Proc. Natl Acad. Sci. USA 103, 3639–3644 (2006).
Beningo, K. A., Dembo, M., Kaverina, I., Small, J. V. & Wang, Y. L. J. Cell Biol. 153, 881–888 (2001).
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Burridge, K., Doughman, R. Front and back by Rho and Rac. Nat Cell Biol 8, 781–782 (2006). https://doi.org/10.1038/ncb0806-781
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DOI: https://doi.org/10.1038/ncb0806-781
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