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Substrate specificity: PI(3)Kγ has it both ways

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Phosphoinositide 3-kinases (PI(3)Ks) are mainly known for their lipid kinase activity in various cellular functions; however, PI(3)Ks also have protein kinase activity. Non-muscle tropomyosin has been identified as a novel protein target for PI(3)Kγ. Phosphorylation of tropomyosin is required for β-adrenergic receptor internalization, providing new insight into PI(3)K function during clathrin-mediated endocytosis.

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Figure 1: Model of βAR internalization.

References

  1. Naga Prasad, S. V. et al. J. Cell Biol. 158, 563–575 (2002).

    Article  Google Scholar 

  2. Naga Prasad, S. V., Jayatilleke, A., Madamanchi, A. & Rockman, H. A. Nature Cell Biol. 7, 785–796 (2005).

    PubMed  Google Scholar 

  3. Walker, E. H., Perisic, O., Ried, C., Stephens, L. & Williams, R. L. Nature 402, 313–320 (1999).

    Article  CAS  Google Scholar 

  4. Dhand, R. et al. EMBO J. 13, 522–533 (1994).

    Article  CAS  Google Scholar 

  5. Vanhaesebroeck, B. et al. EMBO J. 18, 1292–1302 (1999).

    Article  CAS  Google Scholar 

  6. Czupalla, C. et al. J. Biol. Chem. 278, 11536–11545 (2003).

    Article  CAS  Google Scholar 

  7. Lam, K., Carpenter, C. L., Ruderman, N. B., Friel, J. C. & Kelly, K. L. J. Biol. Chem. 269, 20648–20652 (1994).

    CAS  PubMed  Google Scholar 

  8. Bondeva, T. et al. Science 282, 293–296 (1998).

    Article  CAS  Google Scholar 

  9. Shenoy, S. K. & Lefkowitz, R. J. Biochem. J. 375, 503–515 (2003).

    Article  CAS  Google Scholar 

  10. Perry, S. V. Vertebrate tropomyosin: distribution, properties and function. J. Muscle Res. Cell Motil. 22, 5–49 (2001).

    Article  CAS  Google Scholar 

  11. Engqvist-Goldstein, A. E. & Drubin, D. G. Annu. Rev. Cell Dev. Biol. 19, 287–332 (2003).

    Article  CAS  Google Scholar 

  12. Blanchoin, L., Pollard, T. D. & Hitchcock-DeGregori, S. E. Curr. Biol. 11, 1300–1304 (2001).

    Article  CAS  Google Scholar 

  13. DesMarais, V., Ichetovkin, I., Condeelis, J. & Hitchcock-DeGregori, S. E. J. Cell Sci. 115, 4649–4660 (2002).

    Article  CAS  Google Scholar 

  14. Gunning, P. W., Schevzov, G., Kee, A. J. & Hardeman, E. C. Trends Cell Biol. 15, 333–341 (2005).

    Article  CAS  Google Scholar 

  15. Rickert, P., Weiner, O. D., Wang, F., Bourne, H. R. & Servant, G. Trends Cell Biol. 10, 466–473 (2000).

    Article  CAS  Google Scholar 

  16. Laffargue, M. et al. Immunity 16, 441–451 (2002).

    Article  CAS  Google Scholar 

Download references

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  1. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, USA

    Jonathan M. Backer

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  1. Jonathan M. Backer
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Backer, J. Substrate specificity: PI(3)Kγ has it both ways. Nat Cell Biol 7, 773–774 (2005). https://doi.org/10.1038/ncb0805-773

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