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Rab6 and myosin II at the cutting edge of membrane fission

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Rab GTPases regulate the dynamics of transport carriers by participating in their translocation across the cytoplasm, and in their docking and fusion with acceptor compartments. An interaction between Golgi-associated Rab6 and myosin II has now been shown to regulate the fission of Rab6-positive carriers, illuminating a previously unappreciated role for Rab6 and the actomyosin system in carrier biogenesis.

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Figure 1: Rab6 functions in several different intracellular transport pathways.
Figure 2: Myosins and Rabs regulate post-Golgi trafficking to the plasma membrane.

References

  1. Stenmark, H. Nat. Rev. Mol. Cell Biol. 10, 513–25 (2009).

    Article  CAS  Google Scholar 

  2. Miserey-Lenkei S. et al. Nat. Cell Biol. 12, 645–654 (2010).

    Article  CAS  Google Scholar 

  3. Grigoriev, I. et al. Dev. Cell 13, 305–314 (2007).

    Article  CAS  Google Scholar 

  4. Girod, A. et al. Nat. Cell Biol. 1, 423–430 (1999).

    Article  CAS  Google Scholar 

  5. Martinez, O. et al. Proc. Natl Acad. Sci. USA 94, 1828–1833 (1997).

    Article  CAS  Google Scholar 

  6. Martinez, O. et al. J. Cell Biol. 127, 1575–1588 (1994).

    Article  CAS  Google Scholar 

  7. Mallard, F. et al. J. Cell Biol. 156, 653–664 (2002).

    Article  CAS  Google Scholar 

  8. Hill, E., Clarke, M. & Barr, F. A. EMBO J. 19, 5711–5719 (2000).

    Article  CAS  Google Scholar 

  9. Coutelis, J. B. & Ephrussi, A. Development 134, 1419–1430 (2007).

    Article  CAS  Google Scholar 

  10. Yumura, S. J. Cell Biol. 154, 137–146 (2001).

    Article  CAS  Google Scholar 

  11. Araki, N., Hatae, T., Furukawa, A. & Swanson, J. A. J. Cell Sci. 116, 247–257 (2003).

    Article  CAS  Google Scholar 

  12. Lenz, M., Morlot, S. & Roux, A. FEBS Lett. 583, 3839–3846 (2009).

    Article  CAS  Google Scholar 

  13. Römer, W. et al. Cell 140, 540–553.

  14. Deretic, D. et al. J. Cell Sci. 108, 215–224 (1995).

    CAS  PubMed  Google Scholar 

  15. Foth, B. J., Goedecke, M. C. & Soldati, D. Proc. Natl Acad. Sci. USA 103, 3681–3686 (2006).

    Article  CAS  Google Scholar 

  16. Dippold, H. C. et al. Cell 139, 337–351 (2009).

    Article  CAS  Google Scholar 

  17. De Matteis, M. A. & Luini, A. Nat. Rev. Mol. Cell Biol. 9, 273–284 (2008).

    Article  CAS  Google Scholar 

  18. Bielli, P., Casavola, E. C., Biroccio, A., Urbani, A. & Ragnini-Wilson, A. Mol. Microbiol. 59, 1576–1590 (2006).

    Article  CAS  Google Scholar 

  19. Schlager, M. A. et al. EMBO J. 29, 1637–1651.

Download references

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Authors and Affiliations

  1. Carmen Valente is at the Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy and at the Institute of Protein Biochemistry National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy.,

    Carmen Valente

  2. Roman Polishchuk and Maria Antonietta De Matteis are at the Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy and at the Consorzio Mario Negri Sud, Via Nazionale 8, 66030 Santa Maria Imbaro (Chieti), Italy. polish@tigem.it and dematteis@tigem.it,

    Roman Polishchuk & Maria Antonietta De Matteis

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  1. Carmen Valente
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  2. Roman Polishchuk
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  3. Maria Antonietta De Matteis
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The authors declare no competing financial interests.

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Valente, C., Polishchuk, R. & De Matteis, M. Rab6 and myosin II at the cutting edge of membrane fission. Nat Cell Biol 12, 635–638 (2010). https://doi.org/10.1038/ncb0710-635

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