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Movin' on through with Cdc2

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Proteins that control the cell cycle would seem to have little to do with cell migration. However, a recent report indicates that Cdc2, a key cyclin-dependent kinase, can also enhance cell migration. Levels of Cdc2 are upregulated in cells that express high levels of the αvβ3 integrin, a protein that has long been implicated in enhanced migration and invasion of tumour cells.

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Figure 1: A tentative model for Cdc2 in tumour cell migration.

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  1. Department of Pharmacology, University of North Carolina, 1106 Mary Ellen Jones Building, CB# 7365, Chapel Hill, 27599-7365, NC, USA

    Rudy Juliano

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  1. Rudy Juliano
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Juliano, R. Movin' on through with Cdc2. Nat Cell Biol 5, 589–590 (2003). https://doi.org/10.1038/ncb0703-589

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