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A sixth sense for Rab5

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It has long been known that the mammalian small GTPase Rab5 is involved in clathrin-mediated endocytosis. However, most Rab5-interacting proteins are localized to endosomes rather than to the plasma membrane. A newly discovered nucleotide-exchange factor for Rab5 in Caenorhabditis elegans now provides the missing link for activating Rab5 at the plasma membrane.

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Figure 1: Diagram of the classic Rab-GTP/GDP cycle controlling vesicular transport.
Figure 2: Diverse functions of Rab5 on the plasma membrane and on early endosomes.

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Authors and Affiliations

  1. Department of Biological Chemistry, David Geffen School of Medicine at UCLA, 33-257 CHS, Box 951737, Los Angeles, 90095-1737, CA, USA

    Alexander M. van der Bliek

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  1. Alexander M. van der Bliek
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van der Bliek, A. A sixth sense for Rab5. Nat Cell Biol 7, 548–550 (2005). https://doi.org/10.1038/ncb0605-548

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