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Division of labour in ESCRT complexes

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Formation of multivesicular bodies (MVBs) from endosomes or budding of enveloped virus such as HIV-I from the plasma membrane require the ESCRT (endosomal sorting complex required for transport) complexes. An in vitro reconstitution assay unambiguously identifies the function of each ESCRT complex in the sequential events of MVB morphogenesis, from cargo clustering and membrane bud formation to sequestration of cargoes in vesicles, and fission of the vesicles into the lumen of the endosome.

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Figure 1: Schematic representation of the sequence leading to intralumenal vesicle (ILV) morphogenesis by ESCRT complexes.

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  1. Patricia Bassereau is in the Laboratoire PhysicoChimie Curie, Institut Curie, F-75248 Paris Cedex 05, France. patricia.bassereau@curie.fr,

    Patricia Bassereau

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Bassereau, P. Division of labour in ESCRT complexes. Nat Cell Biol 12, 422–423 (2010). https://doi.org/10.1038/ncb0510-422

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