Skip to main content

Advertisement

SpringerLink
Log in

Cancer stem cells: nature versus nurture

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Although all cells within a colon cancer may harbour adenomatous polyposis coli (APC) or β-catenin mutations, activation of Wnt signalling is limited to a subpopulation of cells that display cancer stem cell properties. This activation requires a co-stimulatory signal mediated by hepatocyte growth factor, which is produced by tumour-associated myofibroblasts.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Activation of Wnt signalling in colon cancer stem cells by stromal-derived HGF.
Figure 2: Wnt activation regulates colon stem cells during carcinogenesis.

References

  1. Radtke, F. & Clevers, H. Science 307, 1904–1909 (2005).

    Article  CAS  Google Scholar 

  2. Vermeulen, L. et al. Nat. Cell Biol. 12, 468–476 (2010).

    Article  CAS  Google Scholar 

  3. Korkaya, H. et al. PLoS Biol. 7, e1000121 (2009).

  4. Sato, T. et al. Nature 459, 262–265 (2009).

    Article  CAS  Google Scholar 

  5. Lin, H. J. et al. Biochim. Biophys. Acta 1790, 920–924 (2009).

    Article  CAS  Google Scholar 

  6. Karnoub, A. E. et al. Nature 449, 557–563 (2007).

    Article  CAS  Google Scholar 

  7. Indraccolo, S. et al. Cancer Res. 69, 1314–1323 (2009).

    Article  CAS  Google Scholar 

  8. Yauch, R. L. et al. Nature 455, 406–410 (2008).

    Article  CAS  Google Scholar 

  9. Iliopoulos, D., Hirsch, H. A. & Struhl, K. Cell 139, 693–706 (2009).

    Article  CAS  Google Scholar 

  10. Charafe-Jauffret, E. et al. Cancer Res. 69, 1302–1313 (2009).

    Article  CAS  Google Scholar 

  11. Ginestier, C. et al. J. Clin. Invest. 120, 485–497 (2010).

    Article  CAS  Google Scholar 

  12. Kim, Y. C., Clark, R. J., Ranheim, E. A. & Alexander, C. M. Cancer Res. 68, 10145–10153 (2008).

    Article  CAS  Google Scholar 

  13. Adams, J. M. & Strasser, A. Cancer Res. 68, 4018–4021 (2008).

    Article  CAS  Google Scholar 

  14. Sheridan, C. et al. Breast Cancer Res 8, R59 (2006).

    Article  Google Scholar 

  15. Mani, S. A. et al. Cell 133, 704–715 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hasan Korkaya and Max S.Wicha are at the University of Michigan Comprehensive Cancer Center, 1500 E. Medical Center Dr., 6302 CC, Ann Arbor, MI 48109-5942. mwicha@umich.edu,

    Hasan Korkaya & Max S. Wicha

Authors
  1. Hasan Korkaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Max S. Wicha
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

M.S.Wicha is a scientific consultant for, and holds equity in, OncoMed Pharmaceuticals.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Korkaya, H., Wicha, M. Cancer stem cells: nature versus nurture. Nat Cell Biol 12, 419–421 (2010). https://doi.org/10.1038/ncb0510-419

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0510-419

  • Springer Nature Limited

This article is cited by

Search

Navigation