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When domestiques rebel: kinesins, cadherins and neuronal proliferation

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Conditional knockout of the KAP3 subunit from the kinesin motor KIF3 alters tissue patterning and causes abnormal proliferation of neural progenitor cells in the mouse brain. Impaired transport of N-cadherin to the surface of these cells may be one explanation for how such defects arise.

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Figure 1: Possible mechanisms by which KIF3-mediated transport might regulate neuronal patterning and proliferation.

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Authors and Affiliations

  1. Departments of Medicine and Cell & Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, 60611, IL, USA

    Cara J. Gottardi

  2. Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, 4072, Queensland, Australia

    Nicole R. den Elzen & Alpha S. Yap

Authors
  1. Cara J. Gottardi
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  2. Nicole R. den Elzen
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  3. Alpha S. Yap
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Gottardi, C., den Elzen, N. & Yap, A. When domestiques rebel: kinesins, cadherins and neuronal proliferation. Nat Cell Biol 7, 445–447 (2005). https://doi.org/10.1038/ncb0505-445

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