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Dangerous liaisons: polyglutamine meets HMGB

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Nine inherited neurodegenerative disorders are caused by polyglutamine (polyQ) expansions in diverse proteins. A study now suggests that polyQ-mediated depletion of nonhistone chromatin proteins enhances genotoxic stress induced by the disease protein.

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Figure 1: Schematic representation of a model for inhibiting polyQ-associated cell toxicity by HMGB proteins.

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Authors and Affiliations

  1. Sokol V. Todi and Henry L. Paulson are in the Department of Neurology, University of Iowa College of Medicine, Iowa City, IA, USA. henry-paulson@uiowa.edu,

    Sokol V. Todi & Henry L. Paulson

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  1. Sokol V. Todi
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  2. Henry L. Paulson
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The authors declare no competing financial interests.

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Todi, S., Paulson, H. Dangerous liaisons: polyglutamine meets HMGB. Nat Cell Biol 9, 359–361 (2007). https://doi.org/10.1038/ncb0407-359

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