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Chordin cleavage is sizzling

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Bone Morphogenetic Protein (Bmp) signalling has a critical function in patterning vertebrate and invertebrate embryos. A key regulator of Bmp signalling is Chordin, which binds Bmps and prevents them from interacting with their receptors. Two new papers identify the Frizzled-related protein Sizzled as an unexpected regulator of Chordin stability.

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Figure 1: Bmp signalling in frog and fish embryos.
Figure 2: The role of Sizzled in regulating the Bmp gradient.

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Authors and Affiliations

  1. the Department of Biochemistry, Box 357350, University of Washington, Seattle, 98195–7350, WA, USA

    David Kimelman & Daniel P. Szeto

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  1. David Kimelman
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  2. Daniel P. Szeto
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Kimelman, D., Szeto, D. Chordin cleavage is sizzling. Nat Cell Biol 8, 305–307 (2006). https://doi.org/10.1038/ncb0406-305

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