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Directing NGF's actions: it's a Rap

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Epidermal growth factor and nerve growth factor (NGF) lead to significantly different temporal patterns of extracellular-signal-regulated kinase activation, and differential regulation of Ras and Rap1 have been implicated in mediating this temporal specificity. Now Sasagawa et al. derive a computational model that incorporates the known signalling interactions and identifies key points of regulation that control these processes.

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Figure 1: EGF and NGF lead to different kinetics of ERK activation.
Figure 2: The computational model takes into account many protein interactions, some of which are shown here.

References

  1. Vaudry, D., Stork, P. J., Lazarovici, P. & Eiden, L. E. Science 296, 1648–1649 (2002).

    Article  CAS  Google Scholar 

  2. Chao, M. V. Cell 68, 995–997 (1992).

    Article  CAS  Google Scholar 

  3. Marshall, C. J. Cell 80, 179–185 (1995).

    Article  CAS  Google Scholar 

  4. Traverse, S., Gomez, N., Paterson, H., Marshall, C. & Cohen, P. Biochem. J. 288 (Pt 2), 351–355 (1992).

    Article  CAS  Google Scholar 

  5. Brightman, F. A. & Fell, D. A. FEBS Lett. 482, 169–174 (2000).

    Article  CAS  Google Scholar 

  6. York, R. D. et al. Mol. Cell Biol. 20, 8069–8083 (2000).

    Article  CAS  Google Scholar 

  7. Kao, S., Jaiswal, R. K., Kolch, W. & Landreth, G. E. J. Biol. Chem. 276, 18169–18177 (2001).

    Article  CAS  Google Scholar 

  8. Sasagawa, S., Ozaki, Y., Fujita, K. & Kuroda, S. Nature Cell Biol. 7, 365–373 (2005).

    Article  CAS  Google Scholar 

  9. Schoeberl, B., Eichler-Jonsson, C., Gilles, E. D. & Muller, G. Nature Biotechnol. 20, 370–375 (2002).

    Article  Google Scholar 

  10. Corbalan-Garcia, S., Yang, S. -S., Degenhardt, K. R. & Bar-Sagi, D. Mol. Cell Biol. 16, 5674–5682 (1996).

    Article  CAS  Google Scholar 

  11. Meakin, S. O., MacDonald, J. I., Gryz, E. A., Kubu, C. J. & Verdi, J. M. J. Biol. Chem. 274, 9861–9870 (1999).

    Article  CAS  Google Scholar 

  12. Ichiba, T. et al. J. Biol. Chem. 274, 14376–14381 (1999).

    Article  CAS  Google Scholar 

  13. Jordan, J. D. et al. J. Biol. Chem. (2005).

  14. Wu, C., Lai, C. F. & Mobley, W. C. J. Neurosci. 21, 5406–5416 (2001).

    Article  CAS  Google Scholar 

  15. Ohba, Y., Kurokawa, K. & Matsuda, M. EMBO J. 22, 859–869 (2003).

    Article  CAS  Google Scholar 

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  1. the Oregon Health Sciences University, Vollum Institute L-474, 3181 SW Sam Jackson Park Road, Portland, 97201-3098, OR, USA

    Philip J. S. Stork

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  1. Philip J. S. Stork
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Stork, P. Directing NGF's actions: it's a Rap. Nat Cell Biol 7, 338–339 (2005). https://doi.org/10.1038/ncb0405-338

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