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Cell polarization mechanisms during directed cell migration

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How cells establish and maintain polarity during directed cell migration remains poorly understood. Nishiya et al. now describe an integrin signalling complex that includes paxillin and GIT1, which limits activation of Rac to the leading edge of a migrating cell.

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Figure 1: During polarized cell migration on α4β1 integrin ligands, Nishiya et al. propose that the α4β1 integrin forms a complex with paxillin and GIT1 that is inhibitory to Rac activation through its effects on Arf6.

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  1. Departments of Pharmacology and Pediatrics, University of Wisconsin, 1300 University Avenue, Madison, 53706, WI, USA

    Anna Huttenlocher

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  1. Anna Huttenlocher
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Huttenlocher, A. Cell polarization mechanisms during directed cell migration. Nat Cell Biol 7, 336–337 (2005). https://doi.org/10.1038/ncb0405-336

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