Monoubiquitination of the Fanconi anaemia protein FANCD2 is essential for its activity in DNA repair and tumour suppression. The recent identification of a specific de-ubiquitinating (DUB) enzyme for FANCD2 raises intriguing questions about how and why this tumour suppressor becomes deactivated.
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Venkitaraman, A. DUBing down a tumour suppressor. Nat Cell Biol 7, 332–333 (2005). https://doi.org/10.1038/ncb0405-332
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DOI: https://doi.org/10.1038/ncb0405-332
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